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KMID : 0545120190290121873
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 12 p.1873 ~ p.1881
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Beyond Viral Interferon Regulatory Factors: Immune Evasion Strategies
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Myoung Jin-Jong
Lee Shin-Ae
Lee Hye-Ra
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Abstract
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The innate immune response serves as a first-line-of-defense mechanism for a host against viral infection. Viruses must therefore subvert this anti-viral response in order to establish an efficient life cycle. In line with this fact, Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes numerous genes that function as immunomodulatory proteins to antagonize the host immune system. One such mechanism through which KSHV evades the host immunity is by encoding a viral homolog of cellular interferon (IFN) regulatory factors (IRFs), known as vIRFs. Herein, we summarize recent advances in the study of the immunomodulatory strategies of KSHV vIRFs and their effects on KSHV-associated pathogenesis.
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KEYWORD
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KSHV, viral interferon regulatory factor, immune evasion strategy, PRR-mediated signaling pathway, apoptosis pathway
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